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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

金州勇士队的控球后卫史蒂芬·库里表示,自2013年开始,他每年都会前往中国,而中国的篮球迷也都非常支持他。
会。莫迪一夜之间废除大面额纸币的做法令人震惊,严重扰乱了印度经济。但此举带来了丰厚的政治回报,支撑了莫迪作为愿意采取严厉措施打击腐败的果决领导人的形象。面临2019年的下一届大选,莫迪很有可能想拿出另一项轰动性措施来博取选民的支持。当心,他可能会对那些为了隐藏资产而以他人名义持有房产的富人采取重大行动。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

A Method to the Madness
She said: 'Bobbi's like a little Beyonce, a little madam really.'

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Criminal gangs have been difficult to catch, however, because illegal meats are often hidden among other produce such as fruit and vegetables, and lorry drivers are often bribed to deny any knowledge of it.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

和普通女人一样,我也喜欢超短裙和超长裙——它们通常讨人喜欢,易于穿着。毫无疑问,这些裙子穿在梅根(Megan)和她的朋友们身上更是有力地提醒了我们。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

安妮-西尔万沙萨尼(Anne-Sylvaine Chassany)
优秀老板看起来都会拥有的一个关键是:他们都是解决问题的高手。他们不仅能够发现问题,并能头脑风暴出成功创新的方法来解决问题。
n. 董事,经理,主管,指导者,导演
5. 地缘政治事件。不久之前,石油供应稍有差池,油价就会飙升。比如说2014年初,利比亚内乱造成该国石油出口中断,油价应声上涨。在伊拉克, 极端组织ISIS领了部分地区,石油供应中断的顾虑也造成油价急剧攀升。然而,自此之后,地缘政治事件对油价的影响大为减弱。2014年最后几周,利比亚再现战事。但市场仅在油价短暂上扬后便把这一问题抛诸脑后。不过,历史一再证明,地缘政治危机是对油价影响最大的短期因素之一。(财富中文网)

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 收紧贷款别让刚需躺枪
Perspective

Trends and targets in antiviral phototherapy

*最佳综艺导演:瑞安?麦克福(Ryan McFaul),《艾米?舒莫的内心世界》(Inside Amy Schumer)
2014年在职高管100强课程排行榜冠军是由法国巴黎高等商学院(HEC Paris)、伦敦政治经济学院(LSE)和纽约大学斯特恩商学院(Stern School of Business at New York University)三家合办的Trium课程。排行榜前5位继续由洲际EMBA课程把持。
[in'tendid]
Companies that cut support roles during the downturn, the report notes, will be "adding staff to help make departments more productive and efficient." That trend may herald a happy new year for job hunters.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

本土冠军

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

The parallels between Snapchat, the upstart "sexting" service, and social media behemoth Facebook (FB) in its early days are uncanny. We all know how well Zuckerberg's long bet paid off (not to mention how thoroughly he vanquished those dastardly Winklevoss twins). Could Snapchat's future be just as bright?

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Xinhua reported in 2015 that the MOE and five other central government departments were putting together a task force to ensure that football thrives in the country's schools.
时间:2011-03-08 编辑:beck

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

统筹城市地上地下建设,再开工建设城市地下综合管廊2000公里以上,启动消除城区重点易涝区段三年行动,推进海绵城市建设,使城市既有“面子”、更有“里子”。
More than an hour into Apple’s annual shareholder meeting in February, Tim Cook had patiently fielded questions ranging from its plans for the television market to what he thought of Google Glass. But when one audience member tried to push Apple’s chief executive on the profitability of Apple’s various environmental initiatives, such as its solar-powered data centre, Mr Cook snapped.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 家居上市企业中报8月密集披露
Open Access Review Article

Diagnostic technologies for COVID-19: a review

People (read: your boss) will notice if you go from sporting a uniform of jeans and a T-shirt to showing up in a tailored suit on interview day. This is all the more reason to take the day off from work to interview, but if you don't, dress as usual at the office. And then, Foss says, "leave the premises, and stop in a McDonald's parking lot on the way to the interview to change."
继8月中旬贬值后,人民币在9月和10月有所上涨,但在11月再度走低,昨日人民币汇率收跌至三个月最疲弱水平,为1美元兑6.4082元人民币。“中国周边很多国家自10月份起经历了一些资本外流,中国也未能幸免,”深圳招商证券(China Merchants Securities)经济学家谢亚轩表示。“美元走强势必在一定程度上引发转投美元资产的行为。”

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

2012年春运期间,12306网站系统约售出110万张车票。去年,该系统售出的车票数量同比增加1100万张。
不会。傻子才会去预测足球比赛的结果。最好是作事后诸葛亮。目前已经举办过20届世界杯。其中,巴西(5次捧杯)和德国(4次捧杯)是决赛常客。主场优势有所帮助,东道国赢得了6次奖杯。但是明年的世界杯将在俄罗斯举行,而这位东道主在参赛队伍中排名垫底。
Brazilian soccer fan Joedir Sancho Belmonte missed the 1950 World Cup final to stay home with his sick mother. Sixty-four years later, Belmonte exchanged his original unused ticket for three new tickets to the 2014 final.
白人焦虑推动了今年的西方政治动荡:英国令人震惊地投票决定退出欧盟,美国的唐纳德?J?特朗普(Donald J. Trump)出人意料地获得了共和党的总统提名,挪威、匈牙利、奥地利和希腊的右翼民族主义崛起。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

Along with her friend Chloe, Max is out to uncover the truth behind the mysterious disappearance of fellow student Rachel Amber. With an indie-film feel and an eclectic soundtrack, Life Is Strange stands out from other games by blending the angst of being a teenage girl today with life-and-death situations, and the ability to rewind time. While this gameplay mechanic has been used in many games before, this take on time manipulation feels as unique as the American characters the French developer has created.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Those falls came despite a rise in insurance premium income of 37.3 per cent year-on-year to Rmb1.88tn, while total assets reached Rmb14.27tn, up 15.4 per cent.
该读数最后一次高于50是在2月份。对于该指数来说,是否高于50是区分制造业活动是扩张还是收缩的荣枯线。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

All three factors, says Mr Koepke, were at work in the Mexican currency crisis of 1994-95, when the Fed embarked on a tightening cycle in jumps of 25, 50 and crucially, in November 1994, of 75 basis points.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Bernard Baumohl 作为Economic Outlook Group的首席经济学家,表示他甚至更乐观的认为接下来的两年将会成为至少近十年以来形势最好的两年,他还称“有很多证据充分的表明了经济正在恢复的势头”。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

"We are quite interested in looking at China's efforts and experience in combating corruption. It's a problem we are faced with in South Africa, and one we are tackling with a lot of vigor.Recently, the South African government introduced new measures to combat corruption. This is interesting, because it was immediately after a visit by our minister for public services, who met with the minister here who is responsible for anti-corruption measures.So this is one of the examples of the usefulness of this interaction between our leadership and the leadership of the People's Republic of China."
奖项:尽管大众的高尔夫GTI先拔头筹,但偏向自家人的2015年北美汽车大奖的评审员们还是对福特的野马和F-150皮卡不吝溢美之辞。
2015年期间,难民源源不断涌入希腊、保加利亚、意大利,西班牙、马耳他和塞浦路斯,其中绝大多数,超过80万人是经海路抵达希腊的,大约3600人在横穿北非和意大利间的地中海危险旅途中丧生或失踪。
draft

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

There are 15 Chinese brands in the top 100, one more than last year and a sharp rise on a decade ago, when China Mobile was the only Chinese brand.
出演《美国队长3:英雄决裂》的斯嘉丽-约翰逊排名第三,收入为2500万美元,比去年下降了近30%。
包括中国移动、阿里巴巴和腾讯的16家中国企业进入了该榜单的前100名。
Michael Na表示,尽管韩国已经和中国签署了贸易协议,中国政府仍有足够多的其他方式惩罚韩国政府。
There is "credible evidence" Justin Bieber fathered a child after a backstage encounter with an older female fan, her lawyers have claimed. 一名女性的律师声称

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

罗塞略致力于改善公私合作伙伴关系,并使用这笔收入来挽救面临400亿美元的退休制度,预计不到一年就会崩溃。罗塞略也承诺与美国国会去年成立监督波多黎各财政的联邦控制委员会密切合作,他还说支持与债权人就协助重组一笔近700亿美元的公债谈判。
吊床架

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

互联网已经让世界变成了平面,Facebook让我们大家团结起来,组成一个大家庭。我们的祖父那一辈人是地区的传承者,我们这代人是国家的传承者,而你们则是世界的传承者。你现在和任何人的联系只有4.74个人的距离,到达全球任何有人居住的角落平均只需要两天时间。你可以踏上旅途。无论是非洲、欧洲、印度、中国还是巴西,前往那些能让你学到最多东西的地方,拥抱那个可以教给你最多东西的国度。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

China's innovation indicators show "consistent steady improvement", Gurry said, adding: "And there's no reason to think that that will not continue."

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

4. 贵金属:“都在玩消失!经济周期下行”
让爱情多姿多彩:荷兰培育出彩虹玫瑰(图)
汤姆·佩蒂
circulate圆,环+ion→发生,流通

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

若原油供应严重中断,仍可能会推高油价,但潜在的供应过剩会降低这种可能性。Saxo Bank的大宗商品策略部门主管汉森(Ole Hansen)说,新兴市场的需求曾使得供应如此紧张,因而任何一次供应中断都造成了油价的大幅波动。
Wang Ki-young, a director at South Korea’s culture ministry, said on Friday that Chinese authorities had ordered tourism agencies in Beijing to halt tours to South Korea from mid-March. Mr Wang said the move would be expanded to other provinces.
从投资决策角度来看,2014年是有史以来最糟糕的年景之一,几乎可以说是全盘皆输。除了少数华尔街亿万富豪才玩得起的“股东积极主义”维权策略还算奏效外,没有哪种投资策略在这一年里始终灵光。
n. 典礼,仪式,礼节,礼仪

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Also important to EMBA entrepreneurs was the support of their school and alumni network. About three-quarters of entrepreneurs thought that both the school and their alumni network were helpful or very helpful when setting up their company. “Alumni support was key to getting the idea vetted and getting the right contacts needed for the business”, said one.
教育部还表示,公费留学学生的归国率达到了98%。公费留学生一般选择中国急需的专业,包括工程学、纯科学、农业和医学科学等。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

该版猴票为我国发行的首套生肖邮票,因此颇受追捧。据悉,一枚邮票的价格已经从当时的发行价8分涨至1.2万元,整版价格更是达到150万元。
单词institute 联想记忆:
威廉姆斯的中长期观点可能比巴韦贾更为悲观。他认为,全球出口增速在25至30年的时间里远高于全球GDP增速,意味着“全球化快速发展已经结束”。换句话说,目前的贸易增长放缓是结构性的,而不是周期性的。
In 2016, China's box-office experienced a shock correction, with growth plummeting to just 3.7 percent from a roaring 48 percent rate in 2015.
与比利时接壤的法国已经有大量志愿者出国加入伊斯兰国圣战组织,这个组织占领了伊拉克和叙利亚的大片区域。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

曼谷在2014-15年排行下降主要是由于近年来的政治不稳定。
Angela Merkel's salary as German chancellor is set at 218,400 euros a year ($242,000). The chancellor got a 2% pay rise at the beginning of March, and will get another 2% next February.
数据还显示,网红的分布和经济发展水平也有密切关系,北京、上海、广东、江苏和浙江等较发达地区是网红分布最多的五个地区。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

2015年中国对欧元区的直接投资增长37%,从125亿美元上升至171亿美元。
Though the Dutch financial markets then had none of today’s technology, they employed many of the same practices that traders use today. Investors bought securities, sometimes borrowing money with loans secured by the shares they were buying. In today's language, they bought shares on margin. Lenders protected themselves by demanding a “haircut” – collateral in cash or securities that exceeded the loan amount by a specified percentage. If the value of the securities dropped below that specified percentage, the lender would demand that the investor put up additional money to stay in line with the haircut. If the investor couldn’t come up with the added margin, the lender was entitled to liquidate the securities and recoup the loan amount.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

Perhaps the biggest domestic threat to the 3% growth scenario would be a surprisingly swift hike in interest rates, but from all indications a dovish Federal Reserve is unlikely to take aggressive action in 2015.
办事处副局长卢华东说:“自治区已投资40亿元人民币(约合6亿美元),用于推动贫困地区特色的产业,去年重新安置了77000名贫困人口。”
福特汽车

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

The names of some of these public Facebook groups, Mic reported, were "Harvard Memes for Elitist 1% Tweens", "UCLA Memes for Sick AF Tweens" and "USC Memes for Spoiled Pre-Teens".
摩洛克位于非洲北部地区,被称为通往非洲的一扇大门,主要旅游城市包括首都拉巴特、最大城市卡萨布兰卡、马拉喀什以及阿加迪尔市。
美国的麻省理工斯隆管理学院(MIT Sloan School of Management)位居第五,从而阻止了法国商学院囊括前五名。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 2016年中国建筑玻璃行业市场分析
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

第六步 找到你的“花生”

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

2. Wells Fargo

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Apple Inc., Alphabet Inc.'s Google, and Coca-Cola Co. topped the list of the world's 100 most valuable brands in 2016, while technology and automotive brands dominated the overall rankings, according to a new report from brand consultancy Interbrand.
1.It wasn’t me! – Because some things just aren’t worth taking credit for。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

adj. 方便的,便利的
China is now home to over 80,000 trade markets and total retail sales of consumer goods would reach 30 trillion yuan this year with consumption contributing to about 60 percent of total GDP growth, Gao said.
当然,我不是说你应该盲目地接受摆在面前的一切机会,花时间权衡一下利弊是对的。但当你想要说“No”时,你要确信是出于正当的理由,而不是因为心怀恐惧。
These brands are close to their domestic markets, helping them to gain market share at the expense of global brands, and they are also winning share in new regions, according to BrandZ.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 谁来赋予照明的“灵魂”?
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

"电梯外面很多人,有我的老师,别的家长们,他们看起来都非常焦急,"孙轶潇在获救后表示。
数据显示,在欧洲外的最受游客欢迎20大目的地中,游客的消费主要用于购物,而非就餐。尽管其中很多是世界著名的美食之都。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Here are the top 5 share repurchases authorized so far this year, according to data collected by Birinyi.
Perhaps my favorite profile this year was Kiki Zhao’s stirring depiction of the remarkable Yu Xiuhua, now one of China’s most read poets, a woman with cerebral palsy who lived most of her 41 years on a farm, writing at a low table. She never finished high school, and says she “could write before she could read.” Now, she is invited to places like Stanford University and fends off comparisons to Emily Dickinson.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Soon after he finished his duties, Sun heard loud voices coming from outside.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

"Forty percent of Donald Trump's fortune is tied up in Trump Tower and eight buildings within one mile of it," according to the magazine. "What happens in that micromarket does more to affect the net worth of Donald Trump than anything else in the world. Lately, the neighborhood has been struggling (relatively speaking)."
This 1977 file photo shows Apple co-founder Steve Jobs as he introduces the new Apple II in Cupertino, Calif.
猪肉和蔬菜价格均同比下降了逾8%。
首次发现直接由禽类传染人类的流感病毒,此病毒的传染与接触家禽市场有关。香港有六人死亡。这种病毒之所以不同,是因为它并没有通过传染猪,使猪成为中间宿主,而是直接由鸡传染给人类。另外,年轻人中感染最严重的病症有些与1918年“西班牙流感”病毒相似。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

2. 邻客音(LinkedIn)。品牌喜爱度:47%/排名:309
单词accomplished 联想记忆:

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

安吉利拉瓦尔(Anjli Raval)
Last year was the hottest on earth since record-keeping began in 1880, scientists reported on Friday, underscoring warnings about the risks of runaway greenhouse gas emissions and undermining claims by climate change contrarians that global warming had somehow stopped.
The US box office, which includes totals from Canada, hit $11.1 billion, an 8 percent increase year-over-year, and was credited to several smash hits, including Jurassic World ($652 million domestically), Avengers: Age of Ultron ($459 million) and Inside Out ($356 million).

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

adj. 特指的;指定的
Whatever the underlying cause, last year’s extreme warmth in the West meant that Alaska, Arizona, California and Nevada all set temperature records. Some parts of California essentially had no winter last year, with temperatures sometimes running 10 to 15 degrees above normal for the season. The temperature in Anchorage, Alaska’s largest city, never fell below zero in 2014, the first time that has happened in 101 years of record-keeping for the city.
It is the first time since 2001 that an athlete other than Mayweather Jnr or golfer Tiger Woods topped the earning league.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

n. 平台,站台,月台,讲台,(政党的)政纲
In P2P lending, borrowers are matched with investors, who are encouraged to put their money into the loans due to higher returns than they could get at state banks.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 建筑垃圾三分钟变身新型建材
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Helu came in fourth in Forbes' 2016 list of 1,810 billionaires, behind Gates, Zara's Amancio Ortega and business mogul Warren Buffett, respectively.
美国品牌如Chipotle、德克萨斯仪器公司和通用动力第一次出现在了该榜单上。
Feud: Bette and Joan

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

After year of stars such as Salma Hayek and Gwyneth Paltrow claiming to be vistims of harassment, McGowan has said she understands why Donald Trump supporters hate Hollywood, whose apparent liberalism she says is fake.
Format: Alternating Friday-Saturday classes, with an initial week-long meeting and a week-long international study seminar

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

This is the biggest question hanging over the global economy. And the biggest risk.
该办公室预计今年足球学校的数量将增加到20000所,到2025年时将增加到50000所。
当你需要帮助时,你应该联系你的人脉资源——这正是他们存在的原因。无论你需要他人为你打气,还是想要寻求积累技术经验的建议,你的导师、同事和经理都能为你提供帮助。今天,你可能不知道如何开展某项工作,但你或许足够聪明,能够找到能帮你掌握这种技能的人。一旦你做到这一点,千万不要放松,因为前方总会有其他挑战在等待着你。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Some 695 million netizens used mobile phones to access the Internet in 2016, with a growth rate exceeding 10 percent for the third straight year, the report said. Smartphone-based Internet use accounted for 95.1 percent of all Internet users, up from 90.1 percent in 2015.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

The economy has registered a slower but stable performance with good momentum for growth.
Astronomers confirmed a key part of Einstein’s general theory of relativity in 2016 when they announced that the LIGO array had detected gravitational waves released by the collision of two black holes. The researchers won a Nobel Prize for the discovery. But they’re not done: In October, scientists announced the finding of two dead stars colliding — not only hearing the ripples in space-time they made, but confirming the event visually with powerful telescopes. Collisions of neutron stars are believed to be the source of all heavy metals in the universe, including gold and silver, and the detection by LIGO helps verify accepted explanations of how the chemistry of the universe formed.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Best of luck in the year to come.愿你在未来的一年里,吉星高照。
Beloved TV show characters enter our lives as friends and impact us in crazy ways. They can make us laugh until our sides hurt, cry when things don't go well for them, and call in sick to work when we just can't stop watching and must know what happens. But through it all, we love them. And yet, there's so much that the audience will never know. Some TV shows have dark secrets. Some almost didn't exist at all. Here are some behind the scenes stories of your favorite TV shows.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

Much of the decline in Chinese imports stems from lower commodity prices, which in turn are a result of falling overall demand from China, long the world’s biggest consumer of materials such as iron ore, coal and copper.
1 October

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

In his annual news conference with international reporters, Putin said he is ready to work with any president the American people elect.
However it's framed, 2018 was a strong year for many of China's biggest domestic film studios though.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: 2015橱柜十大品牌最新排名
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

米尔德里德的女儿7个月前遇害,但凶手仍然逍遥法外,主角一怒之下做出了一个大胆的决定:买下了小镇入口三张广告牌并在张贴图片中抨击颇有威望的警长威廉?威洛比。威廉的副手官迪克逊是一个幼稚的妈宝男,有暴力倾向。迪克逊卷入这件事后,米尔德里德和小镇执法系统之间的较量变得愈发激烈了。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

5.X-Men: Apocalypse
"My hair has turned white, half because of housing prices and half because of you reporters." JIANG WEIXIN, member of the CPPCC National Committee and minister of housing and urban-rural development, responding to media questions about government measures to curb housing prices
是的,州市层级的退休金妨碍了复苏。公司养老金也是一个大问题,它加剧了美国的贫富分化:药品公司麦克森(McKesson)的CEO才当14年的老大,但退休时将有1.59亿美元的退休金,而美国一般打工族的收入已经30年止步不前。
A cheery New Year hold lots of happiness for you!给你特别的祝福,愿新年带给你无边的幸福、如意。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

不像这篇文章中其他的人造物品,人工胰腺并不处于前期研究阶段,这个装置确实存在,而且在今年9月份得到了FDA的销售许可

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

去年12月,中国工业利润降幅达到创纪录的8%,显示中国有针对性的刺激计划未能抑制工业放缓,而工业是中国经济的主要推动力。
It all started when Beatty opened the envelope to read the winner for best picture. He looked confused, took a long pause and then glanced at Dunaway. "Come on!" Beatty handed the envelope to Dunaway, who announced: "La La Land!"
Regional

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

伊格尔说:“他非常、非常善于不让这些压力以任何方式破坏苹果正在努力实现的目标。库克的脑海里无疑有要操心的问题,但他确保专门从事苹果最擅长工作的人才不必操心这些问题。”
确实有人有近乎完美的记性,可以从过去经历中检索出大量信息。只是,即使很多人认为这样的记忆已经很完美,他们有的时候也不能准确清晰地记起一些特定的细节。虽然真正完美的记忆并不存在,但你还是可以拥有近乎完美的记忆力,超越这些记忆达人,去抵抗岁月给你带来的疾病和健忘。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 天津“不动产登记一网通”再提速
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

A woman's portrait has not been printed on U.S. paper money since 1896, when Martha Washington, the wife of the first U.S. president, was shown on a one dollar silver certificate.
中国外汇储备出现史无前例的下跌,已经引发市场担心:如果资本外流持续下去,而央行继续捍卫汇率,外储可能迅速蒸发。多数分析师相信,中国央行将被迫缩减干预力度,以免外汇储备进一步枯竭。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

In addition to the growth in P2P lending, a number of online banks and lenders have been created this year — such as Tencent’s Webank, Alibaba’s Mybank and Ant Financial’s Sesame Credit.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Notable newcomers to the list include Cameron Mackintosh, the first theater producer to enter the ranks, WeWork's Adam Neumann and Miguel McKelvey and Pinterest's Ben Silbermann and Evan Sharp.
谎言9:对,我在高中足球队里就是个捣蛋鬼!说谎原因:我想让自己在别人的眼里更加闪亮。
10月份,美国联邦政府停止运转。星巴克CEO霍华德舒尔茨拒绝在所有公司都受到不利影响时袖手旁观。他写了一封请愿书,号召各公司CEO上街游行,给国会施加压力,迫使后者通过预算案。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Indeed, their ability to do so peacefully is among their strengths.
['rep?twɑ:]
日本三巨头:在本田的美国化管理团队将新品投放市场之前,该公司还会原地踏步,尤其是它的讴歌NSX超跑,这款车型已经在各大车展上亮相好几年了,但至今仍未上市。本田CEO卡洛斯o高森一边督促高管团队努力实现他的“三年计划”目标,一边培养继承人。《汽车新闻》报道称,丰田公司在携新产品搬离南加州工厂之前,正处于“马力全开”的状态。
2016年的年度色彩与以往不同,它是两种颜色的组合:粉水晶(Rose Quartz,一种矿物粉色)和宁静蓝天(Serenity,一种淡蓝色)。在该公司的网站上,这两种颜色浑然融为一体,看不清它们的界线。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Stand: Apple CEO Tim Cook fought for workplace protection for the LGBT community
Do you routinely roll your eyes? Do you have a weak handshake? Do you avoid making eye contact? These could all be career killers. People must understand that actions speak louder than words. And the majority of our communication is done through non-verbal cues. People could perceive some of your non-verbal communication habits as rude or unprofessional—and these things could eventually have a significant impact on the advancement of your career.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
From the themed collection: 红星美凯龙抵制天猫双11活动
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

The three bubbles: The Asian Bubble in the early '90s, Dot-com Bubble of the late '90s and what Juckes calls the Great Big Credit Bubble that triggered the 2008 Wall Street meltdown.
Adapted from an online novel Queen of No.11 Agent, the TV series is about the adventure of a female slave Chu Qiao and her romance with a prince Yan Xun.
[k?n's?lt]

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

Maddie has now appeared in three of Sia's videos - Chandelier, Elastic Heart and Big Girls Cry.
The world's second-largest economy is catching up to traditional innovation front-runners, who were led again this year by Switzerland, Sweden, Britain and the United States, said the annual report by the U.N.'s World Intellectual Property Organization (WIPO), INSEAD Business School and Cornell University.

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