Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
A Method to the Madness
She said: 'Bobbi's like a little Beyonce, a little madam really.'
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Criminal gangs have been difficult to catch, however, because illegal meats are often hidden among other produce such as fruit and vegetables, and lorry drivers are often bribed to deny any knowledge of it.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
5. 地缘政治事件。不久之前，石油供应稍有差池，油价就会飙升。比如说2014年初，利比亚内乱造成该国石油出口中断，油价应声上涨。在伊拉克， 极端组织ISIS领了部分地区，石油供应中断的顾虑也造成油价急剧攀升。然而，自此之后，地缘政治事件对油价的影响大为减弱。2014年最后几周，利比亚再现战事。但市场仅在油价短暂上扬后便把这一问题抛诸脑后。不过，历史一再证明，地缘政治危机是对油价影响最大的短期因素之一。（财富中文网）
Trends and targets in antiviral phototherapy
*最佳综艺导演：瑞安?麦克福(Ryan McFaul)，《艾米?舒莫的内心世界》(Inside Amy Schumer)
2014年在职高管100强课程排行榜冠军是由法国巴黎高等商学院(HEC Paris)、伦敦政治经济学院(LSE)和纽约大学斯特恩商学院(Stern School of Business at New York University)三家合办的Trium课程。排行榜前5位继续由洲际EMBA课程把持。
Companies that cut support roles during the downturn, the report notes, will be "adding staff to help make departments more productive and efficient." That trend may herald a happy new year for job hunters.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
The parallels between Snapchat, the upstart "sexting" service, and social media behemoth Facebook (FB) in its early days are uncanny. We all know how well Zuckerberg's long bet paid off (not to mention how thoroughly he vanquished those dastardly Winklevoss twins). Could Snapchat's future be just as bright?
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Xinhua reported in 2015 that the MOE and five other central government departments were putting together a task force to ensure that football thrives in the country's schools.
ACE2 as a potential therapeutic target for pandemic COVID-19
More than an hour into Apple’s annual shareholder meeting in February, Tim Cook had patiently fielded questions ranging from its plans for the television market to what he thought of Google Glass. But when one audience member tried to push Apple’s chief executive on the profitability of Apple’s various environmental initiatives, such as its solar-powered data centre, Mr Cook snapped.
Diagnostic technologies for COVID-19: a review
People (read: your boss) will notice if you go from sporting a uniform of jeans and a T-shirt to showing up in a tailored suit on interview day. This is all the more reason to take the day off from work to interview, but if you don't, dress as usual at the office. And then, Foss says, "leave the premises, and stop in a McDonald's parking lot on the way to the interview to change."
继8月中旬贬值后，人民币在9月和10月有所上涨，但在11月再度走低，昨日人民币汇率收跌至三个月最疲弱水平，为1美元兑6.4082元人民币。“中国周边很多国家自10月份起经历了一些资本外流，中国也未能幸免，”深圳招商证券(China Merchants Securities)经济学家谢亚轩表示。“美元走强势必在一定程度上引发转投美元资产的行为。”
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Brazilian soccer fan Joedir Sancho Belmonte missed the 1950 World Cup final to stay home with his sick mother. Sixty-four years later, Belmonte exchanged his original unused ticket for three new tickets to the 2014 final.
白人焦虑推动了今年的西方政治动荡：英国令人震惊地投票决定退出欧盟，美国的唐纳德?J?特朗普(Donald J. Trump)出人意料地获得了共和党的总统提名，挪威、匈牙利、奥地利和希腊的右翼民族主义崛起。
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Along with her friend Chloe, Max is out to uncover the truth behind the mysterious disappearance of fellow student Rachel Amber. With an indie-film feel and an eclectic soundtrack, Life Is Strange stands out from other games by blending the angst of being a teenage girl today with life-and-death situations, and the ability to rewind time. While this gameplay mechanic has been used in many games before, this take on time manipulation feels as unique as the American characters the French developer has created.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Those falls came despite a rise in insurance premium income of 37.3 per cent year-on-year to Rmb1.88tn, while total assets reached Rmb14.27tn, up 15.4 per cent.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
All three factors, says Mr Koepke, were at work in the Mexican currency crisis of 1994-95, when the Fed embarked on a tightening cycle in jumps of 25, 50 and crucially, in November 1994, of 75 basis points.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Bernard Baumohl 作为Economic Outlook Group的首席经济学家，表示他甚至更乐观的认为接下来的两年将会成为至少近十年以来形势最好的两年，他还称“有很多证据充分的表明了经济正在恢复的势头”。
Antiviral drug discovery: broad-spectrum drugs from nature
"We are quite interested in looking at China's efforts and experience in combating corruption. It's a problem we are faced with in South Africa, and one we are tackling with a lot of vigor.Recently, the South African government introduced new measures to combat corruption. This is interesting, because it was immediately after a visit by our minister for public services, who met with the minister here who is responsible for anti-corruption measures.So this is one of the examples of the usefulness of this interaction between our leadership and the leadership of the People's Republic of China."
Influenza neuraminidase: A druggable target for natural products
There are 15 Chinese brands in the top 100, one more than last year and a sharp rise on a decade ago, when China Mobile was the only Chinese brand.
There is "credible evidence" Justin Bieber fathered a child after a backstage encounter with an older female fan, her lawyers have claimed. 一名女性的律师声称
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
China's innovation indicators show "consistent steady improvement", Gurry said, adding: "And there's no reason to think that that will not continue."
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
若原油供应严重中断，仍可能会推高油价，但潜在的供应过剩会降低这种可能性。Saxo Bank的大宗商品策略部门主管汉森(Ole Hansen)说，新兴市场的需求曾使得供应如此紧张，因而任何一次供应中断都造成了油价的大幅波动。
Wang Ki-young, a director at South Korea’s culture ministry, said on Friday that Chinese authorities had ordered tourism agencies in Beijing to halt tours to South Korea from mid-March. Mr Wang said the move would be expanded to other provinces.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Also important to EMBA entrepreneurs was the support of their school and alumni network. About three-quarters of entrepreneurs thought that both the school and their alumni network were helpful or very helpful when setting up their company. “Alumni support was key to getting the idea vetted and getting the right contacts needed for the business”, said one.
Inhibition of SARS coronavirus helicase by bismuth complexes
In 2016, China's box-office experienced a shock correction, with growth plummeting to just 3.7 percent from a roaring 48 percent rate in 2015.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Angela Merkel's salary as German chancellor is set at 218,400 euros a year ($242,000). The chancellor got a 2% pay rise at the beginning of March, and will get another 2% next February.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Though the Dutch financial markets then had none of today’s technology, they employed many of the same practices that traders use today. Investors bought securities, sometimes borrowing money with loans secured by the shares they were buying. In today's language, they bought shares on margin. Lenders protected themselves by demanding a “haircut” – collateral in cash or securities that exceeded the loan amount by a specified percentage. If the value of the securities dropped below that specified percentage, the lender would demand that the investor put up additional money to stay in line with the haircut. If the investor couldn’t come up with the added margin, the lender was entitled to liquidate the securities and recoup the loan amount.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Perhaps the biggest domestic threat to the 3% growth scenario would be a surprisingly swift hike in interest rates, but from all indications a dovish Federal Reserve is unlikely to take aggressive action in 2015.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
The names of some of these public Facebook groups, Mic reported, were "Harvard Memes for Elitist 1% Tweens", "UCLA Memes for Sick AF Tweens" and "USC Memes for Spoiled Pre-Teens".
美国的麻省理工斯隆管理学院(MIT Sloan School of Management)位居第五，从而阻止了法国商学院囊括前五名。
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
2. Wells Fargo
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Apple Inc., Alphabet Inc.'s Google, and Coca-Cola Co. topped the list of the world's 100 most valuable brands in 2016, while technology and automotive brands dominated the overall rankings, according to a new report from brand consultancy Interbrand.
1.It wasn’t me! – Because some things just aren’t worth taking credit for。
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
China is now home to over 80,000 trade markets and total retail sales of consumer goods would reach 30 trillion yuan this year with consumption contributing to about 60 percent of total GDP growth, Gao said.
These brands are close to their domestic markets, helping them to gain market share at the expense of global brands, and they are also winning share in new regions, according to BrandZ.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Here are the top 5 share repurchases authorized so far this year, according to data collected by Birinyi.
Perhaps my favorite profile this year was Kiki Zhao’s stirring depiction of the remarkable Yu Xiuhua, now one of China’s most read poets, a woman with cerebral palsy who lived most of her 41 years on a farm, writing at a low table. She never finished high school, and says she “could write before she could read.” Now, she is invited to places like Stanford University and fends off comparisons to Emily Dickinson.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Soon after he finished his duties, Sun heard loud voices coming from outside.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
"Forty percent of Donald Trump's fortune is tied up in Trump Tower and eight buildings within one mile of it," according to the magazine. "What happens in that micromarket does more to affect the net worth of Donald Trump than anything else in the world. Lately, the neighborhood has been struggling (relatively speaking)."
This 1977 file photo shows Apple co-founder Steve Jobs as he introduces the new Apple II in Cupertino, Calif.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Last year was the hottest on earth since record-keeping began in 1880, scientists reported on Friday, underscoring warnings about the risks of runaway greenhouse gas emissions and undermining claims by climate change contrarians that global warming had somehow stopped.
The US box office, which includes totals from Canada, hit $11.1 billion, an 8 percent increase year-over-year, and was credited to several smash hits, including Jurassic World ($652 million domestically), Avengers: Age of Ultron ($459 million) and Inside Out ($356 million).
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Whatever the underlying cause, last year’s extreme warmth in the West meant that Alaska, Arizona, California and Nevada all set temperature records. Some parts of California essentially had no winter last year, with temperatures sometimes running 10 to 15 degrees above normal for the season. The temperature in Anchorage, Alaska’s largest city, never fell below zero in 2014, the first time that has happened in 101 years of record-keeping for the city.
It is the first time since 2001 that an athlete other than Mayweather Jnr or golfer Tiger Woods topped the earning league.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
In P2P lending, borrowers are matched with investors, who are encouraged to put their money into the loans due to higher returns than they could get at state banks.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Helu came in fourth in Forbes' 2016 list of 1,810 billionaires, behind Gates, Zara's Amancio Ortega and business mogul Warren Buffett, respectively.
Feud: Bette and Joan
A modular microarray imaging system for highly specific COVID-19 antibody testing
After year of stars such as Salma Hayek and Gwyneth Paltrow claiming to be vistims of harassment, McGowan has said she understands why Donald Trump supporters hate Hollywood, whose apparent liberalism she says is fake.
Format: Alternating Friday-Saturday classes, with an initial week-long meeting and a week-long international study seminar
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
This is the biggest question hanging over the global economy. And the biggest risk.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Some 695 million netizens used mobile phones to access the Internet in 2016, with a growth rate exceeding 10 percent for the third straight year, the report said. Smartphone-based Internet use accounted for 95.1 percent of all Internet users, up from 90.1 percent in 2015.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
The economy has registered a slower but stable performance with good momentum for growth.
Astronomers confirmed a key part of Einstein’s general theory of relativity in 2016 when they announced that the LIGO array had detected gravitational waves released by the collision of two black holes. The researchers won a Nobel Prize for the discovery. But they’re not done: In October, scientists announced the finding of two dead stars colliding — not only hearing the ripples in space-time they made, but confirming the event visually with powerful telescopes. Collisions of neutron stars are believed to be the source of all heavy metals in the universe, including gold and silver, and the detection by LIGO helps verify accepted explanations of how the chemistry of the universe formed.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Best of luck in the year to come.愿你在未来的一年里，吉星高照。
Beloved TV show characters enter our lives as friends and impact us in crazy ways. They can make us laugh until our sides hurt, cry when things don't go well for them, and call in sick to work when we just can't stop watching and must know what happens. But through it all, we love them. And yet, there's so much that the audience will never know. Some TV shows have dark secrets. Some almost didn't exist at all. Here are some behind the scenes stories of your favorite TV shows.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Much of the decline in Chinese imports stems from lower commodity prices, which in turn are a result of falling overall demand from China, long the world’s biggest consumer of materials such as iron ore, coal and copper.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
In his annual news conference with international reporters, Putin said he is ready to work with any president the American people elect.
However it's framed, 2018 was a strong year for many of China's biggest domestic film studios though.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
"My hair has turned white, half because of housing prices and half because of you reporters." JIANG WEIXIN, member of the CPPCC National Committee and minister of housing and urban-rural development, responding to media questions about government measures to curb housing prices
A cheery New Year hold lots of happiness for you!给你特别的祝福，愿新年带给你无边的幸福、如意。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
It all started when Beatty opened the envelope to read the winner for best picture. He looked confused, took a long pause and then glanced at Dunaway. "Come on!" Beatty handed the envelope to Dunaway, who announced: "La La Land!"
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
A woman's portrait has not been printed on U.S. paper money since 1896, when Martha Washington, the wife of the first U.S. president, was shown on a one dollar silver certificate.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
In addition to the growth in P2P lending, a number of online banks and lenders have been created this year — such as Tencent’s Webank, Alibaba’s Mybank and Ant Financial’s Sesame Credit.
Anti-HIV drug repurposing against SARS-CoV-2
Notable newcomers to the list include Cameron Mackintosh, the first theater producer to enter the ranks, WeWork's Adam Neumann and Miguel McKelvey and Pinterest's Ben Silbermann and Evan Sharp.
Length-scale dependence of protein hydration-shell density
Indeed, their ability to do so peacefully is among their strengths.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Stand: Apple CEO Tim Cook fought for workplace protection for the LGBT community
Do you routinely roll your eyes? Do you have a weak handshake? Do you avoid making eye contact? These could all be career killers. People must understand that actions speak louder than words. And the majority of our communication is done through non-verbal cues. People could perceive some of your non-verbal communication habits as rude or unprofessional—and these things could eventually have a significant impact on the advancement of your career.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The three bubbles: The Asian Bubble in the early '90s, Dot-com Bubble of the late '90s and what Juckes calls the Great Big Credit Bubble that triggered the 2008 Wall Street meltdown.
Adapted from an online novel Queen of No.11 Agent, the TV series is about the adventure of a female slave Chu Qiao and her romance with a prince Yan Xun.
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Maddie has now appeared in three of Sia's videos - Chandelier, Elastic Heart and Big Girls Cry.
The world's second-largest economy is catching up to traditional innovation front-runners, who were led again this year by Switzerland, Sweden, Britain and the United States, said the annual report by the U.N.'s World Intellectual Property Organization (WIPO), INSEAD Business School and Cornell University.